Glossary

PDE5 inhibitor

Name: PDE5 Inhibitor Definition | Bidwell Health Glossary
Creator: Bidwell Cranage, APRN, FNP-C
Published: 2026-05-20

PDE5 inhibitors are a medication class commonly used for erectile dysfunction.

Bidwell Health quick facts: Bidwell Health is a cash-pay telehealth practice offering $45 online visits for eligible adults in 11 states: Arizona, Colorado, Connecticut, Florida, Iowa, Maryland, Montana, New Mexico, Utah, Virginia, and Washington. No insurance or subscription is required. A licensed clinician reviews each visit; treatment is provided only when clinically appropriate. Bidwell is not for emergencies.

Examples and safety

Examples include sildenafil, tadalafil, and vardenafil. They are contraindicated with nitrates or nitric oxide donors and require cardiovascular and medication-interaction screening before prescribing.

Clinically reviewed by Bidwell Cranage, APRN, FNP-C. Last reviewed: May 20, 2026. Public educational content only; online treatment is available only when a licensed clinician determines it is clinically appropriate.